After studying Biomedical Sciences at KU Leuven, Leen started her PhD at the REGA institute of the KU Leuven in 2015. During five years, she investigated how the gut flora (gut microbiome) of healthy infants develops in their first year of life.
She specialized in the many aspects of microbiology and genomics, but also in bioinformatics and biostatistics.
Working experience
Patent Attorney, V.O. (March 2025)
Trainee Patent Attorney, V.O. (2021-2025)
PhD student, Rega Institute KU Leuven (2015-2021)
Education
PhD in Biomedical Sciences, KU Leuven (2020)
MSc in Biomedical Sciences, KU Leuven (2015)
BSc in Biomedical Sciences, KU Leuven (2013)
Publications
Conceição-Neto, N., Zeller, M., Lefrère, H., De Bruyn, P., Beller, L., Deboutte, W., Yinda, C. K., Lavigne, R., Maes, P., Ranst, M. Van, Heylen, E. & Matthijnssens, J. Modular approach to customise sample preparation procedures for viral metagenomics: A reproducible protocol for virome analysis. Sci. Rep. 5, 16532 (2015).
Yinda, C. K., Zeller, M., Conceição-Neto, N., Maes, P., Deboutte, W., Beller, L., Heylen, E., Ghogomu, S. M., Van Ranst, M. & Matthijnssens, J. Novel highly divergent reassortant bat rotaviruses in Cameroon, without evidence of zoonosis. Sci. Rep. 6, 34209 (2016).
Yinda, C. K., Ghogomu, S. M., Conceição-Neto, N., Beller, L., Deboutte, W., Vanhulle, E., Maes, P., Van Ranst, M. & Matthijnssens, J. Cameroonian fruit bats harbor divergent viruses, including rotavirus H, bastroviruses, and picobirnaviruses using an alternative genetic code. Virus Evol. 4, vey008 (2018).
Theuns, S., Vanmechelen, B., Bernaert, Q., Deboutte, W., Vandenhole, M., Beller, L., Matthijnssens, J., Maes, P. & Nauwynck, H. J. Nanopore sequencing as a revolutionary diagnostic tool for porcine viral enteric disease complexes identifies porcine kobuvirus as an important enteric virus. Sci. Rep. 8, 9830 (2018).
Vanmechelen, B., Bletsa, M., Laenen, L., Lopes, A. R., Vergote, V., Beller, L., Deboutte, W., Korva, M., Avšič Županc, T., Goüy de Bellocq, J., Gryseels, S., Leirs, H., Lemey, P., Vrancken, B. & Maes, P. Discovery and genome characterization of three new Jeilongviruses, a lineage of paramyxoviruses characterized by their unique membrane proteins. BMC Genomics 19, 617 (2018).
Yinda, C. K., Vanhulle, E., Conceição-Neto, N., Beller, L., Deboutte, W., Shi, C., Ghogomu, S. M., Maes, P., Van Ranst, M. & Matthijnssens, J. Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses. mSphere 4, (2019).
Beller, L. & Matthijnssens, J. What is (not) known about the dynamics of the human gut virome in health and disease. Curr. Opin. Virol. 37, 52–57 (2019).
Shi, C., Beller, L., Deboutte, W., Yinda, K. C., Delang, L., Vega-Rúa, A., Failloux, A.-B. & Matthijnssens, J. Stable distinct core eukaryotic viromes in different mosquito species from Guadeloupe, using single mosquito viral metagenomics. Microbiome 7, 121 (2019).
Wollants, E., Beller, L., Beuselinck, K., Bloemen, M., Lagrou, K., Reynders, M. & Van Ranst, M. A decade of enterovirus genetic diversity in Belgium. J. Clin. Virol. 121, 104205 (2019).
Deboutte, W., Beller, L., Yinda, C. K., Maes, P., de Graaf, D. C. & Matthijnssens, J. Honey-bee–associated prokaryotic viral communities reveal wide viral diversity and a profound metabolic coding potential. Proc. Natl. Acad. Sci. U. S. A. 117, 10511–10519 (2020).
Thijssen, M., Tacke, F., Beller, L., Deboutte, W., Yinda, K. C., Nevens, F., Laleman, W., Van Ranst, M. & Pourkarim, M. R. Clinical relevance of plasma virome dynamics in liver transplant recipients. EBioMedicine 60, 103009 (2020).
Simsek, C., Corman, V. M., Everling, H. U., Lukashev, A. N., Rasche, A., Maganga, G. D., Binger, T., Jansen, D., Beller, L., Deboutte, W., Gloza-Rausch, F., Seebens-Hoyer, A., Yordanov, S., Sylverken, A., Oppong, S., Sarkodie, Y. A., Vallo, P., Leroy, E. M., Bourgarel, M., Yinda, K. C., Van Ranst, M., Drosten, C., Drexler, J. F. & Matthijnssens, J. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions. MBio 12, (2021).
On a patent application (or patent), inventors employed by an employer have at least the right to be named. In some countries, such as the United States, there is an additional reason to name the correct inventors. If the wrong persons are named as inventors in such a country, the patent may not be enforceable.Continue reading
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The development of new inventions is often characterized by the cooperation of different parties. It is advisable to agree on the ownership on potential inventions already before the cooperation is started in a cooperation agreement to avoid intensive discussions or even a suit regarding unlawful ownership later when a patent application shall be or has […]Continue reading
For anyone with some experience in IP who wants to deepen their knowledge of IP, V.O. Patents & Trademarks is organizing an Advanced course on Thursday, December 11. Continue reading